Glaucoma Cell Biology Laboratory
Department of Ophthalmology and Visual Sciences

 

Publications

 







Becker, K., Klein, H., Simon, E., Viollet, C, Haslinger, C., Leparc, G., Schultheis, C., Chong, V., Kuehn, M.H., Fernandez-Albert, F., Bakker, R.A. (2021) In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy. Sci Rep In Press

Kuehn, M.H., Vranka, J.A., Wadkins, D., Jackson, T., Cheng, L., Ledolter, J. (2021) Circumferential trabecular meshwork cell density in the human eye. Exp Eye Res. Epub ahead of print PubMed pdf


Gramlich, O.W., Godwin, C.R., Heuss, N.D., Gregerson, D.S., Kuehn, M.H. (2020) T and B lymphocyte deficiency in Rag1-/- mice reduces retinal ganglion cell loss in experimental glaucoma. Invest Ophthalmol Vis Sci 61(14):18 PubMed

Grozdanic, S.D., Lazic, T., Kecova H., Mohan, K., Kuehn, M.H. (2020) Presumed Cancer-Associated Retinopathy (CAR) mimicking Sudden Acquired Retinal Degeneration Syndrome (SARDS) in canines Vet Ophthalmol 24(2):125-155 PubMed

Harper, M.M., Boese, E.A., Kardon, R.H., Ledolter, J., Kuehn, M.H. (2020) High Correlation between Glaucoma Treatment with Topical Prostaglandin Analogs and BDNF Immunoreactivity in Human Retina. Curr. Eye Res. 27:1-7. PubMed

Cheng, L., Zhu, W., Wareham, L.K., Buys, E., Kuehn, M.H. (2020) Trabecular meshwork restoration in primary open-angle glaucoma using stem cells. In: J. R. Samples and P. Knepper (Eds.), Glaucoma Research 2020-2022, Kugler Publications, Amsterdam, 2020, pp. 29-40. pdf

Zhu, W., Godwin, C.R., Cheng, L., Scheetz, T.E., Kuehn, M.H. (2020) Transplantation of iPSC-TM stimulates division of trabecular meshwork cells in human eyes. Sci. Rep. 10:2905 PubMed pdf


Harper, M.M, Hedberg-Buenz, A., Herlein, J., Abrahamson, E.E., Anderson, M.G., Kuehn, M.H., Kardon, R.H., Poolman, P, Ikonomovic, M.D. (2019) Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 60(7):2716-2725 PubMed pdf

Oliver, J.A.C., Ricketts, S.L., Kuehn, M.H., Mellersh, C.S. (2019) Primary closed angle glaucoma in the Basset Hound: Genetic Investigations using genome wide association and RNA-sequencing strategies Mol. Vis. 25:93-105 PubMed pdf

Grozdanic, S., Lazic, T., Kecova, H. Mohan, K., Kuehn, M.H. (2019) Optical coherence tomography and molecular analysis of sudden acquired retinal degeneration syndrome (SARDS) eyes suggests the immune-mediated nature of retinal damage. Vet. Ophthalmology 22(3):305-327 PubMed pdf

Kuehn, M.H., Mishra, R., Deonovic, B.E., Miller, K.N., McCormack, S.E., Liu, G.T., Kupersmith, M.J., Wall, M., and the NORDIC IIHTT Study Group (2019) Genetic Survey of Adult Onset Idiopathic Intracranial Hypertension J. Neuro Ophthalmol. 39(1):50-55 PubMed pdf Supplemental Materials


van der Heide, C.J., Alward, W.L.M., Flamme-Wiese, M., Riker, M., Syed, N., Carter, K., Kuehn, M.H., Mullins, R.F., Fingert, J.H. (2018) Histochemical analysis of glaucoma caused by a MYOC mutation in a human donor eye. Ophthalmology Glaucoma 1(2):132–138 PubMed pdf

Keller, K.E., Bhattacharya, S.K., Borras, T., Brunner, T.M., Chansangpetch, S., Clark, A.F., Dismuke, W.M., Du, Y., Elliott ,M.H., Ethier, C.R., Faralli, J.A,. Freddo, T.F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M.A., Kaufman, P.L., Kelley, M.J., Knepper, P.A., Kopczynski, C.C., Kuchtey, J.G., Kuchtey, R.W., Kuehn, M.H., Lieberman, R.L., Lin, S.C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C.M., Overby, D.R., Pattabiraman, P.P., Raghunathan, V.K., Rao, P.V., Rhee, D.J., Chowdhury, U.R., Russell, P., Samples, J.R., Schwartz, D., Stubbs, E.B., Tamm, E.R., Tan, J.C., Toris, C.B., Torrejon, K.Y., Vranka, J.A., Wirtz, M.K., Yorio, T., Zhang, J., Zode, G.S., Fautsch, M.P., Peters, D.M., Acott, T.S., Stamer, W.D. (2018) Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 171:164-173 PubMed pdf


Zhu, W., Jain, A., Gramlich, O.W., Tucker, B.A., Sheffield, V.C., Kuehn, M.H. (2017) Restoration of Aqueous Humor Outflow following Transplantation of iPSC-derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma. Invest Ophthalmol Vis Sci. 58(4):2054-2062. PubMed pdf

Muenster, S., Lieb, W.S., Fabry, G., Allen, K.N., Kamat, S.S., Guy, A.H., Dordea, A.C., Teixeira, L., Tainsh, R.E., Yu, B., Zhu, W., Ashpole, N.E., Malhotra, R., Brouckaert, P., Bloch, D.B., Scherrer-Crosbie, M., Stamer, W.D., Kuehn, M.H., Pasquale, L,R., Buys, E.S. (2017) The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. Invest Ophthalmol Vis Sci. 58(11):4826-4835 PubMed pdf

Williams, P.A., Marsh-Armstrong, N., Howell, G.R., Bosco, A., Danias, J., Simon. J., Di Polo, A., Kuehn, M.H., Przedborski, S., Raff, M., Trounce, I. (2017) Neuroinflammation in glaucoma: A new opportunity. Exp Eye Res. 157:20-27. PubMed


Chirco, K.R., Hazlewood, R.J., Miller, K., Workalemahu, G., Jampol, L.M., Lesser, G.R., Mullins, R.F., Kuehn, M.H., Fingert, J.H. (2016) MMP19 expression in the human optic nerve. Mol. Vis. 22:1429-1436 PubMed pdf

Lavik, E.B., Kuehn, M.H., Shoffstall, A., Atkins, K., Dumitrescu, A.V., Kwon, Y.H. (2016) Sustained Delivery of Timolol Maleate for over 90 days via Subconjunctival Injection. J. Ocul. Pharmacol. Ther. 32(10):642-649 PubMed pdf

Zhu, W, Gramlich, O.W., Laboissonniere, L., Jain, A., Sheffield, V.C., Trimarchi, J.M., Tucker, B.A., Kuehn, M.H. (2016) Transplantation of iPSC-derived trabecular meshwork cells rescues glaucoma phenotypes in a mouse model of disease. Proc. Nat. Acad. Sci USA. 113(25):E3492-500 PubMed pdf

Gramlich, O.W., Burand, A.J., Brown, A.J., Deutsch, R.J., Kuehn, M.H., Ankrum, J.A. (2016) Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury model: Toward an off-the-shelf Therapy. Sci. Rep. 6:26463 PubMed pdf

Kuehn, M.H., Lipsett, K.A., Menotti-Raymond, M., Whitmore, S.S., Scheetz, T.E. David, V.A., O'Brien, S.J., Zhao, Z., Jens, J.K., Snella, E.A., Ellinwood, N.W., McLellan, G.J. (2016) A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus). PLoS One 5;11(5):e0154412 PubMed pdf

Sohn, E.H, van Dijk, H.W., Jiao, C., Kok, P.H.B, Jeong, W., Demarkaya, N., Garmager, A., Wit, F., Kucukevcilioglu, M., van Velthoven, M.E.J., DeVries, H., Mullins, R.F., Kuehn, M.H., Schlingemann, R.O., Sonka, M., Verbraak, F.D., Abramoff, M.D. (2016) Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc. Nat. Acad. Sci USA 113(19):E2655-64 PubMed


Gramlich, O.W., Ding, Q.J., Zhu, W., Cook, A., Anderson, M.G., Kuehn, M.H. (2015) Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients. Acta Neuropathol. Commun. 3:56 PubMed pdf

Yang, X., Hondur, G., Li, M., Cai, J., Klein, J.B., Kuehn, M.H., Tezel, G. (2015) Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina. Invest Ophthalmol Vis Sci. 56(10):5816-5830 PubMed pdf

Ahram, D.F., Alward, W.L., Kuehn M.H. (2015) The Genetic Mechanisms of Primary Angle Closure Glaucoma Eye 29(10): 1251–1259 PubMed pdf

Ahram, D.F., Grozdanic, S.D., Kecova, H., Henkes, A., Collin, R.W., Kuehn, M.H. (2015) Variants in Nebulin (NEB) Are Linked to the Development of Familial Primary Angle Closure Glaucoma in Basset Hounds. PLoS One 4;10(5):e0126660 PubMed pdf

Hazlewood, R.J., Roos, B.R., Solivan-Timpe, F., Honkanen, R.A., Jampol, L.M., Gieser, S.C., Meyer, K.J., Mullins, R.F., Kuehn, M.H., Scheetz, T.E., Kwon, Y.H., Alward, W.L., Stone, E.M., Fingert, J.H. (2015) Heterozygous Triplication of Upstream Regulatory Sequences Leads to Dysregulation of Matrix Metalloproteinase 19 (MMP19) in Patients with Cavitary Optic Disc Anomaly (CODA). Hum Mutat. 36(3):369-78 PubMed


Ding Q.J., Zhu W., Cook A.C., Anfinson K.R., Tucker B.A., Kuehn M.H. (2014) Induction of Trabecular Meshwork Cells from Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci. 55:7065-72 PubMed pdf

Kuehn, M.H. (2014) Immune Phenomena in Glaucoma and Conformational Disorders: Why is the Second Eye Not Involved? J. Glaucoma S59-61 PubMed pdf

Ahram, D., Kecova, H., Cook, A.C., Grozdanic, S.D., Kuehn, M.H. (2014) Identification of Genetic Loci Associated with Primary Angle Closure Glaucoma in the Basset Hound. Mol. Vis. 20:497-510 PubMed pdf


Fernandez de Castro, J.P., Mullins, R.F., Manea, A.M., Hernandez, J., Wallen, T.J., Kuehn, M.H. (2013) Lipofuscin in Human Glaucomatous Optic Nerves. Exp. Eye Res. 111:61-6 PubMed pdf

Scheetz, T.E., Fingert, J.H., Wang, K., Kuehn, M.H., Knudtson, K.L., Alward, W.L.M., Boldt, H.C., Russell, S.R., Folk, J.C., Casavant, T.L., Braun, T.A., Clark, A.F., Edwin M. Stone, E.M., Sheffield, V.C. (2013) A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel loci. PLoS One 2013;8(3):e58657 PubMed pdf


Ding, Q.J., Cook, A.C, Dumitrescu, A.V., Kuehn, M.H. (2012) Lack of immunoglobulins does not prevent C1q binding to RGC and does not alter the progression of experimental glaucoma. Invest. Ophthalmol Vis. Sci. 53(10):6370-77 PubMed pdf

Mullins, R.F., Kuehn, M.H., Radu, R.A., Enriquez, G.S., East, J.S., Schindler, E.I., Travis, G.H., Stone, E.M. (2012) Autosomal Recessive Retinitis Pigmentosa Due To Abca4 Mutations: Clinical, Pathologic And Molecular Characterization Invest. Ophthalmol Vis. Sci. 53(4):1883-94 PubMed


Yang, X., Luo, C., Cai, J., Powell, D., Yu, D., Kuehn, M.H., Tezel, G. (2011) Neurodegenerative and Inflammatory Pathway Components linked to TNF-α/TNFR1 Signaling in the Glaucomatous Human Retina. Invest. Ophthalmol Vis. Sci. 52(11):8442-54 PubMed

Zode, G.S., Kuehn, M.H., Nishimura, D.Y., Searby, C.C., Mohan, K., Grozdanic, S.D., Bugge, K., Anderson, M.G., Clark, A.F., Stone, E.M., Sheffield, V.C.(2011) Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma J. Clinical Invest. 121(9):3542-53 PubMed

Sigle, K.J., Camaño-Garcia, G., Carriquiry, A.L., Betts, D.M., Kuehn, M.H., McLellan, G.J. (2011) The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma. Vet. Ophthalmol. 1:48-53 PubMed

Kuehn, M.H, Wang, K., Roos, B., Stone, E.M., Kwon, Y.H. Alward, W.L.M. Mullins, R.F., Fingert, J.H. (2011) Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort. Mol. Vis. 17:430-435 PubMed pdf

Mullins, R.F., Dewald, A.D., Streb, L.M., Wang, K., Kuehn, M.H., Stone, E.M. (2011) Elevated membrane attack complex in human choroid with high risk complement factor H genotypes. Exp. Eye Res. 93(4):565-7 PubMed

Rutz-Mendicino, M.M., Snella, E.M., Jens, J.K., Gandolfi, B., Carlson, S.A., Kuehn, M.H., McLellan, G.J., Ellinwood, N.M. (2011) Removal of potentially confounding phenotypes from a siamese-derived feline glaucoma breeding colony. Comp Med. 61(3):251-7.PubMed

Harper, M.M., Grozdanic, S.D., Blits, B., Kuehn, M.H., Zamzow, D., Buss, J.E., Kardon, R.H., Sakaguchi, D.S. (2011) Transplantation of BDNF secreting mesenchymal stem cells provides neuroprotection in chronic hypertensive rat eyes. Invest. Ophthalmol Vis Sci. 52(7):4506-15 PubMed

Lavik, E., Kuehn, M.H., Kwon, Y.H. (2011) Novel drug delivery systems for glaucoma. Eye 25(5):578-86 PubMed

Trantow, C.M., Cuffy, T.L., Fingert, J.H., Kuehn, M.H., Anderson, M.G. (2011) Microarray analysis of iris gene expression in mice with mutations influencing pigmentation. Invest. Ophthalmol Vis Sci. 52(1):237-48 PubMed pdf


Jiang, B., Harper, M.M., Kecova, H., Adamus, G., Kardon, R.H., Grozdanic, S.G., Kuehn. M.H. (2010) Neuroinflammation in Advanced Canine Glaucoma. Mol. Vis. 16:2092-108 PubMed pdf

Luo, C., Yang. X, Kain, A., Powell, D., Kuehn, M.H., Tezel, G. (2010) Glaucomatous Tissue Stress and the Regulation of Immune Response Through the Glial Toll-like Receptor Signaling. Invest. Ophthalmol Vis. Sci. 51(11):5697-707 PubMed pdf

Tezel, G., Yang, X., Luo, C., Kain, A., Powell, D., Kuehn, M.H., Kaplan, H.J. (2010) Oxidative Stress and the Regulation of Complement Activation in Human Glaucoma. Invest. Ophthalmol Vis. Sci. 51(10):5071-82 PubMed pdf

Grozdanic, S.D., Lazic, T., Kuehn, M.H., Harper, M.M, Kardon, R.H, Kwon, Y.H., Lavik, E.B., Sakaguchi, D.S. (2010) Exogenous modulation of intrinsic optic nerve neuroprotective activity. Graefes Arch Clin Exp Ophthalmol. 248(8):1105-16 PubMed pdf

Tezel, G., Yang, X., Luo, C, Cai, J., Kain, A.D., Powell, D.W., Kuehn, M.H., Pierce, W.M. (2010) Hemoglobin Expression and Regulation in Glaucoma: Insights into Retinal Ganglion Cell Oxygenation. Invest. Ophth. Vis. Sci. 51:907-919 PubMed pdf

Grozdanic, S.D., Kecova, H., Harper M.M., Nilaweera, W.U., Kuehn, M.H., Kardon, R.H. (2010) Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Invest. Ophth. Vis. Sci. 51:255-263 PubMed pdf

Lively, G.D., Jiang, B., Hedberg-Buenz, A., Chang, B., Petersen, G.E., Wang, K., Kuehn, M.H., Anderson, M.G. (2010) Genetic Dependence of Central Corneal Thickness among Inbred Strains of Mice. Invest. Ophthalmol Vis. Sci. 51:160–171 PubMed pdf


Kwon, Y.H., Fingert, J.H., Kuehn, M.H., Alward, W.L.M. (2009) Mechanism of Disease: Primary Open Angle Glaucoma. N. Engl. J. Med. 360(11): 1113-1124 PubMed pdf

Tezel, G., and the Fourth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group (2009) The role of glia, mitochondria, and the immune system in glaucoma. Invest. Ophthalmol Vis. Sci. 50(3):1001-12 PubMed pdf

Kuehn, M.H., Kim, C.Y., Jiang, B, Dumitrescu, A.V., Kwon, Y.H. (2008) Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Exp. Eye Res. 87: 89-95 PubMed pdf

Ostojic, J., Grozdanic, S.D., Syed, N.A., Hargrove M.S., Trent III J.T., Kuehn M.H., Kwon Y.H., Kardon R.H., Sakaguchi D.S. (2008) Patterns of Distribution of the Oxygen-Binding Globins, Neuroglobin and Cytoglobin, in Human Retina. Arch. Ophthalmol. 126(11):1530-6 PubMed

Ostojic, J., Grozdanic, S.D., Syed, N.A., Hargrove M.S., Trent III J.T., Kuehn M.H., Kwon Y.H., Kardon R.H., Sakaguchi D.S. (2008) Neuroglobin and Cytoglobin Distribution in the Anterior Eye Segment: a Comparative Immunohistochemical Study. J. Histochem. Cytochem. 56:863-872 PubMed

Mullins, R.F, Kuehn, M.H., Faidley, E.A., Syed, N.A., Stone, E.M. (2007) Differential Macular and Peripheral Expression of Bestrophin in Human Eyes and its Implication for Best Disease. Invest Ophthalmol Vis Sci. 48:3372-3380 PubMed


Kim, C.Y., Kuehn, M.H., Clark, A.F., Kwon, Y.H. (2006) Gene Expression Profile of the Adult Human Retinal Ganglion Cell Layer. Mol. Vision 12: 1640-8 PubMed pdf

Kim, C.Y., Kuehn, M.H., Anderson, M.G., and Kwon, Y.H. (2006) Intraocular Pressure Measurement in Mice: A Comparison between Goldmann and Rebound Tonometry. Eye 20: 1-8 PubMed

Kuehn, M.H, Kim, C.Y., Ostojic, J, Bellin, M, Alward, W.L.M, Stone, E.M., Sakaguchi, D.S., Grozdanic, S.D. Kwon, Y.H. (2006) Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp. Eye Res. 83 (3):620-8 PubMed pdf

Mullins, R.F, Skeie, J.M., Malone, E.A, Kuehn, M.H. (2006) Macular and Peripheral Distribution of ICAM-1 in the Human Choriocapillaris and Retina. Mol. Vis. 12: 224-25 PubMed pdf

Ostojic J., Sakaguchi D. S., de Lathouder Y., Hargrove M. S., Trent III J. T., Kwon Y.H., Kardon R. H., Kuehn M. H., Betts D. M., Grozdanic S. D., (2006). Neuroglobin and Cytoglobin: Oxygen-Binding Proteins in Retinal Neurons. Invest Ophthalmol Vis Sci 47(3): 1016-23 PubMed

Kuehn, M.H., Fingert, J.H., Kwon, Y.H. (2005) Retinal Ganglion Cell Death in Glaucoma: Mechanisms and Neuroprotective Strategies. Ophthalmol Clin North Am. 18, 383-395 PubMed pdf

Stone, E.M, Braun, T.A., Russell, S.R, Kuehn, M.H., Lotery, A.J., Moore, P.A, Christopher G. Eastman, C.G, Casavant, T.C., Sheffield, V.C. (2004) Missense Variations in the Fibulin 5 Gene and age-related macular degeneration. N. Engl. J. Med. 351(4): 346-53. PubMed

Kuehn, M.H., Stone, E.S., Hageman, G.S. (2001) Organization of the Human IPM 200 Gene (IMPG2) and its Evaluation as a Candidate Gene in Age-related Macular Degeneration, Retinitis Pigmentosa and Leber Congenital Amaurosis. Invest. Ophthalmol. Vis. Sci. 13:3123-3129 PubMed

Alagramam, K.N., Yuan, H., Kuehn, M.H. et al. (2001) Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum. Mol. Genet. 10:1709-18. PubMed

Ruiz, A., Kuehn, M.H., Stone, E.S., Hageman, G.S., Bok, D. (2001) Characterization of the lecithin retinol acyltransferase (LRAT) gene structure and evaluation of it’s involvement in ocular disease. Invest. Ophthalmol. Vis. Sci. 1:31-37 PubMed

Kuehn, M.H., Wietecki, D. T., Hageman, G. S. (2000) Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150, Mol. Vis. 6:148-156. PubMed pdf

Kuehn, M.H., Hageman, G.S. (1999) Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan. Matrix Biology 18:509-518 PubMed pdf

Kuehn, M.H., Hageman, G.S. (1999) Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans. Molec. Cell. Biol. Res. Commun 2:103-110 PubMed pdf

Gorin, M.B., Breitner, J.C.S., De Jong, P.T.V.M., Hageman, G.S., Klaver, C.C.W., Kuehn, M.H. and Seddon, J.M. (1999) The genetics of age-related macular degeneration. Mol. Vis. 5:29 PubMed pdf

Hageman, G.S., Kuehn, M.H. (1998) Biology of the retina-IPM-RPE interface, in The Pigmented Retinal Epithelium: Current Aspects of Function and Disease., Marmor, M., and Wolfensberger, T., Eds., Oxford University Press, New York, pp. 417-454

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